Not really any different to changing gear with the right hand and steering with the left!!! Not sure I get your point?
I've driven right and left hand drive cars and yes it's a bit odd for the first few gear changes but then just begins to feel normal after that.
The first time a drive a LHD car was a 5 series BMW. I kept on trying to change gear with the windows winder - not that tells you how long ago that was.