Yep.
If it's a new one, it will not only Be Double-DIN, but also have the 'quadlock' conector which mates directly with the RNS-E.
A little programming with VAG-COM, one wire to relocate if you have Bose (ignore this step if you don't have Bose) and you're pretty much rockin.
Oh, £10 worth of antenna (if you don't have the sharkfin) or quickly run a FAKRA extension (if you DO have the sharkfin) is the only other thing to do.
Swapping the head unit over took me 5 minutes beginning to end. Programming with VAG-COM took 10 minutes with a leisurely cup of PG tips and a smile. I have the Sharkfin, but I still just plugged in the in-dash antenna instead... did it while the head unit was out, took 20 seconds, stuck it to a metal bracket (it's magenetic, further secured with a cable tie) and the whole thing was 15 minutes.
The rear antenna diversity system is different, but unless you're in a VERY weak reception area, it's just fine. I drove to Fort Lauderdale and back on Tuesday including driving through some fairly isolated parts, and I was able to get dozens of stations at all times.
If you're getting a new one, it'll be a doddle. If you have a VAG-COM it'll be under 15 minutes. If you Don't have a VAG-COM, either take this as the opportunity to buy one (Highly recommended!), or find a friendly local who DEOS have one, and ply him with Old Speckled Hen, Guinness, or whatever.
Doddle. -Good luck!
Keith