Takin a wild stab in the dark.......... are you runnin zonealarm ?
I am and that stopped me running VCDS v10.6 too, any prior versions of VCDS were fine.
if you are; or even if you aren't running zonealarm, try shutting down your internet security program and ending any associated services within task manager (lke zonealarm forcefield etc)
Once these are closed, then it should run (you may have to end the VCDS process too and restart it.
Mk5 Golf R32
Gruppe M Carbon Cold Ait induction Kit, Full Stainless Non Resonated Supersprint Exhaust, TVS Stage 1 Tuning, Recaro Wing Back Reats, Alpine IVA-W505R Double DIN All in One Multimedia Station with Bluetooth
Rosstech HEX-USB+CAN Owner with VCDS 10.6 (Happy to help anybody out in the North West)