Sharpest Tongue in the West
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you can stick it everywhere, to be honest it depends on how much weight you want to add to your car, because like you rightly point out, it weighs a ton.
The best bet is a 6-10 inch square behind your speakers double layer is better too, so ideally stuck to the door skins. And then any metal that is open to the back of a speaker really if you imagine the door as the speaker cabinet. The more you use the better sound you'll get, but the more weight you'll add, so it's horses for courses as they say.
I also like to make a gasket form the stuff and mount it between the speaker and the door or wherever its screwed to.
If you have a sub in the boot, then do the inside of the boot door and sides of the boot again, against the inside of the outer panel.
I assume you're not doing this to minimise road noise, which is another use for the stuff but involves sticking in different places, like the floorpan!