I certainly wouldnt put nikasil and alusil in the same boat. Nikasil was used by BMW for their 6 and 8 pot motors in the mid 90's and was a spectacular failure, the nikasil reacts with sulphur in the petrol and ruins the bore walls. BMW switched to alusil after a few years and that sorted the problems.
I wasnt suggesting running the V8 as an NA motor, i was suggesting starting out with an NA block as a base, and then turbocharge it, rather than trying to find an RS6 lump.
RS6 engines make big power and i've never heard of any major failures? MTM also did a conversion where they decanted the RS6 internals into a standard 40v block so it would bolt up to a manual tranny, so again, the block must be reasonably comparable.
You also need to remember that for a given power figure, the V8 will be much less stressed. If you say you want 700hp, your looking at 175hp per cylinder from a 1.8T, 116hp per cylinder from a V6/VR6 or 87hp per cylinder from a V8.
In terms of cylinder loadings, that 700hp V8 is under the same sort of load as a 350hp I4, and i'm sure you'll agree 350hp is pretty trivial for an I4 engine (i'd certainly happily run a stock 1.8T at 350hp, perhaps with some rods thrown in as a safety). Add to that the cylinders in the V8 are larger (~525cc rather than ~450cc in the 1.8T and vr6 engines) which further reduces cylinder/piston loading.
Audi also ditched the 5v design when they went FSI, so it cant have been better by enough to keep it around once they'd developed the direct injection system...
I agree, the fact that reworking the V8 engines bores etc is dodgy ground does place a question mark over it, but i think the results from the RS6 motors show that they are easily capable of the sorts of power you'll get from a VR6 build.
Theres a big build thread on motorgeek with a guy thats running a 32v V8 in a B4 coupe, with a pair of T3 super 60's running 20psi, and all hes done to the motor itself is fitted stacked headgaskets. I'm sure that motor must be running over 600hp with those pressures out of those turbos, and its a completely stock motor internally barring the extra head gaskets.